Detalhe da pesquisa
1.
An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of Activated PI3 kinase Delta Syndrome.
Pulm Pharmacol Ther
; 79: 102201, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36841351
2.
Organ-on-a-chip: current gaps and future directions.
Biochem Soc Trans
; 50(2): 665-673, 2022 04 29.
Artigo
Inglês
| MEDLINE | ID: mdl-35437569
3.
PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation.
BMC Immunol
; 22(1): 78, 2021 12 17.
Artigo
Inglês
| MEDLINE | ID: mdl-34920698
4.
Organ-on-chip applications in drug discovery: an end user perspective.
Biochem Soc Trans
; 49(4): 1881-1890, 2021 08 27.
Artigo
Inglês
| MEDLINE | ID: mdl-34397080
5.
An investigation of the anti-inflammatory effects and a potential biomarker of PI3Kδ inhibition in COPD T cells.
Clin Exp Pharmacol Physiol
; 44(9): 932-940, 2017 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-28508433
6.
Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition.
Am J Respir Crit Care Med
; 194(8): 961-973, 2016 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27064380
7.
Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome.
Lancet
; 385 Suppl 1: S55, 2015 Feb 26.
Artigo
Inglês
| MEDLINE | ID: mdl-26312877
8.
Targeting phosphoinositide 3-kinase δ for allergic asthma.
Biochem Soc Trans
; 40(1): 240-5, 2012 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-22260698
9.
Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.
Clin Pharmacokinet
; 61(2): 281-293, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34458976
10.
The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and Recruitment.
Front Immunol
; 12: 671756, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33953730
11.
Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials.
Int J Chron Obstruct Pulmon Dis
; 16: 1621-1636, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34113094
12.
Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.
J Med Chem
; 64(18): 13780-13792, 2021 09 23.
Artigo
Inglês
| MEDLINE | ID: mdl-34510892
13.
Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target.
J Med Chem
; 63(2): 638-655, 2020 01 23.
Artigo
Inglês
| MEDLINE | ID: mdl-31855425
14.
Kinetic assay for characterization of spleen tyrosine kinase activity and inhibition with recombinant kinase and crude cell lysates.
Anal Biochem
; 384(1): 56-67, 2009 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18762159
15.
Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase.
J Cell Biol
; 163(1): 97-107, 2003 Oct 13.
Artigo
Inglês
| MEDLINE | ID: mdl-14530380
16.
The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.
Bioorg Med Chem Lett
; 19(19): 5760-3, 2009 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19703773
17.
Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage.
Sci Rep
; 9(1): 19085, 2019 12 13.
Artigo
Inglês
| MEDLINE | ID: mdl-31836766
18.
Antithrombotic potential of GW813893: a novel, orally active, active-site directed factor Xa inhibitor.
J Cardiovasc Pharmacol
; 52(1): 66-71, 2008 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-18645410
19.
Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.
J Med Chem
; 59(15): 7239-51, 2016 08 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27429068
20.
Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.
J Med Chem
; 58(18): 7381-99, 2015 Sep 24.
Artigo
Inglês
| MEDLINE | ID: mdl-26301626